High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F19%3A43914979" target="_blank" >RIV/62156489:43210/19:43914979 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26620/19:PU131625

Result on the web

<a href="https://doi.org/10.1016/j.aca.2018.09.006" target="_blank" >https://doi.org/10.1016/j.aca.2018.09.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aca.2018.09.006" target="_blank" >10.1016/j.aca.2018.09.006</a>

Result language

angličtina

Original language name

High-throughput deposition of chemical reagents via pen-plotting technique for microfluidic paper-based analytical devices

Original language description

The deposition of chemical reagent inks on paper is a crucial step in the development and fabrication of microfluidic paper-based analytical devices (mu PADs). A pen-plotting approach, delivering chemical ink deposition using technical pens filled with reagents and inserted into a desktop electronic plotter, is shown herein to be a versatile, low-cost, simple, rapid, reproducible, and high-throughput solution. The volume of the deposited ink was quantified gravimetrically, confirming that nanoliter volumes of reagents can be deposited reproducibly (e.g. 7.55 +/- 0.37 nL/mm for a plotting speed of 10 cm/s) in detection zones of mu PADs, typically spatially defined using wax printing. This approach was further investigated with regard to deposition of reagents in different geometrical forms (circular and linear), so demonstrating its applicability for preparation of mu PADs with flexible design and application. By adjusting the plotting speed for linear deposition, lines with a relatively large range of widths (approximate to 628-1192 mm) were created. Circular deposition was also demonstrated via delivery of reagents within wax printed circular fluidic barriers of a range of diameters (inner diameter = 1.5-7 mm). These capabilities were practically demonstrated via the fabrication of mu PADs, based upon differing detection principles for determination of aluminum in natural waters using Morin as the fluorescent reagent. Traditional mu PADs based on digital image colorimetry (DIC) were produced using circular deposition, whilst distance-based mu PADs exploited linear deposition. Both types of mu PADs developed using this method showed excellent precision for determination of trace concentrations of aluminium (average RSDs = 3.38% and 6.45%, and LODs = 0.5 ng (0.25 ppm) and 2 ng (0.5 ppm), for traditional and distance-based detection, respectively).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10406 - Analytical chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Analytica Chimica Acta

ISSN

0003-2670

e-ISSN

—

Volume of the periodical

1047

Issue of the periodical within the volume

24 January

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

115-123

UT code for WoS article

000453384400013

EID of the result in the Scopus database

2-s2.0-85054713769