Study of selected signaling pathways genes that play an important role in bone metabolism in laying hens

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919586" target="_blank" >RIV/62156489:43210/20:43919586 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Study of selected signaling pathways genes that play an important role in bone metabolism in laying hens
Original language description
Due to the balanced activity of osteoclasts, the bone-reabsorbing cells, and osteoblasts, the bone-forming cells, bone remodeling is lifelong process, which can be influenced by number of factors. The key role in the control of osteoclastogenesis and osteoblastogenesis play signaling pathways. This work was primary focused on detection of single nucleotide polymorphisms in selected genes that are part of those signaling pathways that regulates skeletal development and homeostasis. The study of these genes is of great value for skeletal health and diseases in laying hens. The polymorphisms of five genes (WISP1, SOST, TNFSF11, TNFRSF11A and TNFRSF11B) was studied in order to survey their relationship with parameters of bones in hens of ISA Brown hybrids (bone breaking strength, length, width and bone mass). PCR and sequencing were used to determine the polymorphisms and each marker were tested in sixteen samples. No polymorphisms were found in selected gene regions in the experimental group of animals, which would show associations with the observed bone parameters of laying hens.
Czech name
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Czech description
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Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2020: Proceedings of International PhD Students Conference
ISBN
978-80-7509-765-1
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
424-429
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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