Study of selected genes of Wnt signaling pathway in relation to the parameters in the bone tissue of the laying hens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F22%3A43920854" target="_blank" >RIV/62156489:43210/22:43920854 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.sjbs.2021.12.024" target="_blank" >https://doi.org/10.1016/j.sjbs.2021.12.024</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sjbs.2021.12.024" target="_blank" >10.1016/j.sjbs.2021.12.024</a>

Result language

angličtina

Original language name

Study of selected genes of Wnt signaling pathway in relation to the parameters in the bone tissue of the laying hens

Original language description

The Wnt signaling pathway plays a critical role in almost all aspects of skeletal development and homeostasis. Many studies suggest the importance of this signaling pathway in connection with bone metabolism through many skeletal disorders caused by mutations in Wnt signaling genes. The knowledge gained through targeting this pathway is of great value for skeletal health and diseases, for example of increased bone mass in the case of osteoporosis. Our objective was to focus on the detection of single nucleotide polymorphisms and investigate the associations between possible polymorphisms in selected genes that are part of those signaling pathways and parameters of bones in hens of ISA Brown hybrids (bone breaking strength, length, width, and bone mass). Different regions of the GPR177, ESR1 and RUNX2 genes were studied, using PCR and sequencing, in a total of forty-eight samples for each marker. Thirteen polymorphisms have been discovered in selected regions of studied genes, whereas these polymorphisms were only within the GPR177 gene. Eight of these polymorphisms were synonymous and five were in the intron. The tested regions of the ESR1 and RUNX2 genes were monomorphic. The only statistically significant difference was found within the GPR177 gene (exon 2) and the bone length parameter, in the c.443 + 86G&gt;A polymorphism. However, this polymorphism was found in the intron, and no other one was found within the selected regions to show associations with the observed bone parameters.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40201 - Animal and dairy science; (Animal biotechnology to be 4.4)

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Saudi Journal of Biological Sciences

ISSN

1319-562X

e-ISSN

2213-7106

Volume of the periodical

29

Issue of the periodical within the volume

4

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

2526-2531

UT code for WoS article

000798983400064

EID of the result in the Scopus database

2-s2.0-85122297282