Associations of SOST and TNFSF11 genes polymorphisms with bone parameters in broilers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F21%3A43921822" target="_blank" >RIV/62156489:43210/21:43921822 - isvavai.cz</a>
Result on the web
<a href="https://mendelnet.cz/media/mnet_2021_full.pdf" target="_blank" >https://mendelnet.cz/media/mnet_2021_full.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Associations of SOST and TNFSF11 genes polymorphisms with bone parameters in broilers
Original language description
In modern broiler lines, increasing demands are placed on skeletal integrity, where these lines are often characterized by poor calcification and high bone porosity. Bone abnormalities, as disruption of the normal skeletal growth process and homeostasis, are usually complex and lead to increased affinity for bone damage and many bone diseases. Bone quality traits can be improved by genetic tools, given the additive genetic background of these traits. In this study, attention was focused mainly on the search for polymorphisms in selected candidate genes that play an important role in bone metabolism. We studied the associations of single nucleotide polymorphisms in several regions of two genes (SOST and TNFSF11) with selected bone parameters (bone breaking strength, length, width, bone mass) in fast (Ross 308) and slow (Hubbard M22BxJA87A) growing broilers, whereas the individual hybrid lines were also compared on the basis of the monitored bone parameters. A total of 48 animals were tested. PCR and sequencing were used to determine the polymorphisms. In selected regions of studied genes, thirteen polymorphisms have been discovered. Five of these polymorphisms were in the introns and three were synonymous. Only one polymorphism was found in selected gene regions in the experimental group of animals, which showed associations with bone breaking strength, but this polymorphism was found in the intron. Other polymorphisms, especially those found in the exon, did not show associations with the observed bone parameters.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
40201 - Animal and dairy science; (Animal biotechnology to be 4.4)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
MendelNet 2021: Proceedings of International PhD Students Conference
ISBN
978-80-7509-821-4
ISSN
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e-ISSN
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Number of pages
6
Pages from-to
399-404
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 10, 2021
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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