Synthesis of PLGA nanoparticles with entrapped antibiotic mupirocin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43919624" target="_blank" >RIV/62156489:43210/20:43919624 - isvavai.cz</a>
Result on the web
<a href="https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf" target="_blank" >https://mnet.mendelu.cz/mendelnet2020/mnet_2020_full.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis of PLGA nanoparticles with entrapped antibiotic mupirocin
Original language description
Infections caused by resistant strains of bacteria have reached a critical level calling for increasingly effective delivery system of drugs to prevent and treat these infections. PLGA nanoparticles (NP) with mupirocin encapsulated could be good for better and quicker wound healing process. The aim of the experiment is to develop PLGA NPs with entrapped mupirocin and determine basic characteristic of it. Mupirocin is effective antibiotic in the fight against mentioned infection. For synthesis of these NPs was used emulsion evaporation method. Characterization of prepared NPs consisted of measuring size (141.1 +- 9.3 nm), zeta potential (-21.9 +- 4.6 mV) and morphology by method TEM. Also, we did a release profile of mupirocin from NPs. Loading capacity was calculated as 2.34 μg and entrapped efficiency as 22.4%.
Czech name
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Czech description
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Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
MendelNet 2020: Proceedings of International PhD Students Conference
ISBN
978-80-7509-765-1
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
589-593
Publisher name
Mendelova univerzita v Brně
Place of publication
Brno
Event location
Brno
Event date
Nov 11, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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