Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43410%2F17%3A43910984" target="_blank" >RIV/62156489:43410/17:43910984 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.2147/IJN.S124318" target="_blank" >https://doi.org/10.2147/IJN.S124318</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/IJN.S124318" target="_blank" >10.2147/IJN.S124318</a>

Result language

angličtina

Original language name

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Original language description

Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%+-1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%+-2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%+-2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Nanomedicine

ISSN

1176-9114

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

14 March

Country of publishing house

NZ - NEW ZEALAND

Number of pages

11

Pages from-to

2021-2031

UT code for WoS article

000396151900001

EID of the result in the Scopus database

2-s2.0-85015865201