The Effect of Acid pH Modifiers on the Release Characteristics of Weakly Basic Drug from Hydrophlilic-Lipophilic Matrices
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872198" target="_blank" >RIV/62157124:16370/13:43872198 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1208/s12249-013-0019-1" target="_blank" >http://dx.doi.org/10.1208/s12249-013-0019-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1208/s12249-013-0019-1" target="_blank" >10.1208/s12249-013-0019-1</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of Acid pH Modifiers on the Release Characteristics of Weakly Basic Drug from Hydrophlilic-Lipophilic Matrices
Original language description
The solubility of weakly basic drugs within passage though GI tract leads to pH-dependent or even incomplete release of these drugs from extended release formulations and consequently to lower drug absorption and bioavailability. The aim of the study wasto prepare and evaluate hydrophilic-lipophilic (hypromellose-montanglycol wax) matrix tablets ensuring the pH-independent delivery of the weakly basic drug verapamil-hydrochloride by an incorporation of three organic acidifiers (citric, fumaric, and itaconic acids) differing in their concentrations, pK a, and solubility. The dissolution studies were performed by the method of changing pH values, which better corresponded to the real conditions in the GI tract (2h at pH1.2 and then 10h at pH6.8). Withinthe same conditions, pH of matrix microenvironment was measured. To determine relationships between the above mentioned properties of acidifiers and the monitored effects (the amount of released drug and surface pH of gel layer in select
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AAPS PharmSciTech
ISSN
1530-9932
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1341-1348
UT code for WoS article
000330232300008
EID of the result in the Scopus database
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