Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F04%3A00000155" target="_blank" >RIV/62157124:16170/04:00000155 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/04:00000207

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species

Original language description

Neuroimmune modulation depends on many molecular structures, where the substantial role plays adenosine receptors in cooperation with dopamine. This is especially exerted when the system undergo stressful conditions or tumor target cell recognition. Ourstudy was designed to assess the effect of adenosine A 1 (CCPA), A 3 (NECA), and A 2A (CPCA) receptor agonists in natural killer (NK) cell-mediated cytotoxicity across several mammalian species (mouse, rat, human and pig). The experimental models of restraint stress or transplanted tumors under dopaminergic impact in mice were followed. An inhibitory action of A 2A agonist at high concentration (10-5M) were demonstrated, while A 1 and A 3 adenosine agonists don´t influence significantly the NK cells effector function. On the other hand, low concentrations of A 2A agonist stimulated the cytotoxicity in healthy unconditioned animals, and contrary evoked inhibition under stress of tumor pressure. Moreover, the final effects of adenosine re

Czech name

Začlenění adenosiových receptorů do NK cytotoxicity u různých druhů savců

Czech description

Začlenění adenosiových receptorů do NK cytotoxicity u různých druhů savců

Type

D - Article in proceedings

CEP classification

ED - Physiology

OECD FORD branch

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Project

<a href="/en/project/GA304%2F01%2F0850" target="_blank" >GA304/01/0850: Ontogenetic development of immune systém cdells and their surface structures</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

80. fyziologické dny

ISBN

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ISSN

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e-ISSN

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Number of pages

1

Pages from-to

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Publisher name

neudán

Place of publication

neudán

Event location

Praha

Event date

Feb 3, 2004

Type of event by nationality

CST - Celostátní akce

UT code for WoS article

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