Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A17033128" target="_blank" >RIV/68081707:_____/03:17033128 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.

Original language description

The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Development Research

ISSN

0272-4391

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

303-311

UT code for WoS article

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EID of the result in the Scopus database

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