Fas ligand in formation of hard tissues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F14%3A43873327" target="_blank" >RIV/62157124:16170/14:43873327 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fas ligand in formation of hard tissues
Original language description
Among activation of apoptotic machinery, Fas (CD95)/FasL (CD178) were suggested to act in cell proliferation and differentiation. Expression of Fas and FasL was reported during tooth and bone formation. The examination of gld mice showed increased totalbody bone mass and number of osteoblasts in long bones. However, Fas and FasL functions in osteogenesis remain controversial. As most of studies dealing with Fas/FasL system in bone formation were performed in endochondral models, we turned to intramembranous bones. The aim of our study was to investigate functions of FasL in development of the mandibular and alveolar bones using immunohistochemistry and impact of FasL deficiency by microCT examination of gld mice. This project continues our earlier published investigations of Fas/FasL in prenatal molar tooth development. Heads at embryonic (E) 12.5, 15.5, 17.5 and postnatal (P) 0, 1, 4, 11 days were used for immunohistochemical analysis. FasL was localized in the dental epithelium, den
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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