FasL is a catabolic factor in alveolar bone homeostasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00568970" target="_blank" >RIV/67985904:_____/23:00568970 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13750" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13750</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jcpe.13750" target="_blank" >10.1111/jcpe.13750</a>
Alternative languages
Result language
angličtina
Original language name
FasL is a catabolic factor in alveolar bone homeostasis
Original language description
Aim: Fas ligand (FasL) belongs to the tumour necrosis factor superfamily regulating bone turnover, inflammation, and apoptosis. The appendicular and axial skeleton phenotype of mature Fasl(gld) mice has been reported. The impact of FasL on the alveolar bone providing support for the teeth at mature stages under healthy and induced inflammatory conditions remains unknown. Materials and Methods: We performed a phenotypical analysis of mice carrying the homozygous Fasl(gld) mutation and wild-type (WT) mice (C57BL/6) under healthy conditions and upon ligature-induced periodontitis. After 12 days, micro-computed tomography analysis revealed the distance between the cement enamel junction and the alveolar bone crest. Additional structural parameters, such as the bone volume fraction (BV/TV) and the periodontal ligament space volume, were measured. Histological analyses were performed to visualize the catabolic changes at the defect site. Results: Healthy Fasl(gld) mice were found to have more periodontal bone than their WT littermates. Fasl(gld) had no significant effect on inflammatory osteolysis compared to WT controls with ligatures. Histology revealed eroded surfaces at the root and in the inter-proximal bone in both strains. Conclusions: Our findings suggest that FasL is a catabolic factor in alveolar bone homeostasis but it does not affect the inflammatory osteolysis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GF19-29667L" target="_blank" >GF19-29667L: FasL in osteogenesis, periodontal health and disease</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Periodontology
ISSN
0303-6979
e-ISSN
1600-051X
Volume of the periodical
50
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
396-405
UT code for WoS article
000890832000001
EID of the result in the Scopus database
2-s2.0-85142602948