Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43873545" target="_blank" >RIV/62157124:16170/15:43873545 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0012160615301809" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0012160615301809</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ydbio.2015.09.007" target="_blank" >10.1016/j.ydbio.2015.09.007</a>

Result language
angličtina
Original language name
Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo
Original language description
Cranial neural crest cells form the majority of the facial skeleton. However exactly when the pattering information and hence jaw identity is established is not clear. We know that premigratory neural crest cells contain a limited amount of information about the lower jaw but the upper jaw and facial midline are specified later by local tissue interactions. The environmental signals leading to frontonasal identity have been explored by our group in the past. Altering the levels of two signaling pathways(Bone Morphogenetic Protein) and retinoic acid (RA) in the chicken embryo creates a duplicated midline on the side of the upper beak complete with egg tooth in place of maxillary derivatives (Lee et al., 2001). Here we analyze the transcriptome 16 h after bead placement in order to identify potential mediators of the identity change in the maxillary prominence. The gene list included RA, BMP and WNT signaling pathway genes as well as transcription factors expressed in craniofacial devel
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GA304%2F09%2F0725" target="_blank" >GA304/09/0725: Signaling pathways contributing to jaw identity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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