BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F16%3A43874205" target="_blank" >RIV/62157124:16170/16:43874205 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/16:00468150 RIV/00216224:14310/16:00099784
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/DVDY.24422" target="_blank" >10.1002/DVDY.24422</a>
Alternative languages
Result language
angličtina
Original language name
BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner
Original language description
Background: Lineage tracing has shown that most of the facial skeleton is derived from cranial neural crest cells. However, the local signals that influence postmigratory, neural crest-derived mesenchyme also play a major role in patterning the skeleton. Here, we study the role of BMP signaling in regulating the fate of chondro-osteoprogenitor cells in the face. Results: A single Noggin-soaked bead inserted into stage 15 chicken embryos induced an ectopic cartilage resembling the interorbital septum within the palate and other midline structures. In contrast, the same treatment in stage 20 embryos caused a loss of bones. The molecular basis for the stage-specific response to Noggin lay in the simultaneous up-regulation of SOX9 and downregulation of RUNX2 in the maxillary mesenchyme, increased cell adhesiveness as shown by N-cadherin induction around the beads and increased RA pathway gene expression. None of these changes were observed in stage 20 embryos. Conclusions: These experiments demonstrate how slight changes in expression of growth factors such as BMPs could lead to gain or loss of cartilage in the upper jaw during vertebrate evolution. In addition, BMPs have at least two roles: one in patterning the skull and another in regulating the skeletogenic fates of neural crest-derived mesenchyme. Developmental Dynamics 245: 947-962, 2016. (C) 2016 Wiley Periodicals, Inc.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental dynamics
ISSN
1058-8388
e-ISSN
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Volume of the periodical
245
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
947-962
UT code for WoS article
000384752100005
EID of the result in the Scopus database
2-s2.0-84981288403