Essential role of Bmp signaling and its positive feedback loop in the early cell fate evolution of chordates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423225" target="_blank" >RIV/68378050:_____/13:00423225 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ydbio.2013.07.021" target="_blank" >http://dx.doi.org/10.1016/j.ydbio.2013.07.021</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ydbio.2013.07.021" target="_blank" >10.1016/j.ydbio.2013.07.021</a>
Alternative languages
Result language
angličtina
Original language name
Essential role of Bmp signaling and its positive feedback loop in the early cell fate evolution of chordates
Original language description
In chordates, early separation of cell fate domains occurs prior to the final specification of ectoderm to neural and non-neural as well as mesoderm to dorsal and ventral during development. Maintaining such division with the establishment of an exact border between the domains is required for the formation of highly differentiated structures such as neural tube and notochord. We hypothesized that the key condition for efficient cell fate separation in a chordate embryo is the presence of a positive feedback loop for Bmp signaling within the gene regulatory network (GRN), underlying early axial patterning. Here, we therefore investigated the role of Bmp signaling in axial cell fate determination in amphioxus, the basal chordate possessing a centralizednervous system. Pharmacological inhibition of Bmp signaling induces dorsalization of amphioxus embryos and expansion of neural plate markers, which is consistent with an ancestral role of Bmp signaling in chordate axial patterning and ne
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Developmental Biology
ISSN
0012-1606
e-ISSN
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Volume of the periodical
382
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
538-554
UT code for WoS article
000325670800015
EID of the result in the Scopus database
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