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General caspase inhibition in chondrocytes - RNASeq based comparison of OPH and FMK inhibitors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F21%3A43879383" target="_blank" >RIV/62157124:16170/21:43879383 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    General caspase inhibition in chondrocytes - RNASeq based comparison of OPH and FMK inhibitors

  • Original language description

    An RNASeq based approach was used to search for a comprehensive overview of the impact of general caspase inhibition on the transcriptome profile of chondrocytes in vitro. The impact of two mostly used general caspase inhibitors, Z-VAD-FMK (FMK) and Q-VD-OPH (OPH), was examined and compared. The experiments revealed a statistically significant impact in expression of 542 genes in the FMK samples and 351 genes in the OPH samples compared to controls. Among the affected genes, 252 were upregulated and 290 were downregulated in the FMK-treated samples, whereas, expression of 163 was increased and expression of 188 genes decreased in the OPH-treated chondrocytes. Many of the affected genes are associated with pathological conditions, such as osteoarthritis and rheumatoid arthritis. The results support the importance of caspases in cartilage homeostasis and development of diseases and points to novel regulatory mechanisms.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    <a href="/en/project/GA19-12023S" target="_blank" >GA19-12023S: Novel physiological functions of pro-apoptotic cysteine proteases in endochondral ossification</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů