Coagulation profile in bitches with pyometra: Standard tests and thromboelastography

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F25%3A43882824" target="_blank" >RIV/62157124:16170/25:43882824 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.17221/16/2025-VETMED" target="_blank" >https://doi.org/10.17221/16/2025-VETMED</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/16/2025-VETMED" target="_blank" >10.17221/16/2025-VETMED</a>

Result language

angličtina

Original language name

Coagulation profile in bitches with pyometra: Standard tests and thromboelastography

Original language description

This study aimed to determine coagulation changes in bitches with pyometra based on a series of coagulation tests and thromboelastography (TEG), and to assess the incidence of disseminated intravascular coagulation (DIC). Eighteen bitches with pyometra and thirty-four control bitches were examined. Haematological, biochemical, and following haemostasis parameters were measured, including: prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin activity (AT), and levels of fibrinogen (FBG), D-dimers (DD), tissue factor (TF), plasminogen (PLG), tissue plasminogen activator inhibitor 1 (TPAI-1), and thromboelastography. DIC was considered present if three or more of these parameters were abnormal: platelet count (&lt;153 x 10(9)/l), PT (&gt;8.1 s), aPTT (&gt;25.5 s), FBG (&lt;0.6 g/l), DD (&gt;0.2 mg/l), and AT (&lt;107%). Significant differences were found in the PT, aPTT, FBG, DD, TPAI-1, clotting time, alpha-angle, and maximal amplitude. According to our scoring system, two patients were DIC positive. The study found alterations in several coagulation tests and hypercoagulable TEG tracings in bitches with pyometra, which point to excessive activation of coagulation, delayed fibrinolysis, and the presence of DIC. No patient bled abnormally, which may suggest that DIC is not overt in the majority of pyometra patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

40301 - Veterinary science

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Veterinární medicína

ISSN

0375-8427

e-ISSN

1805-9392

Volume of the periodical

70

Issue of the periodical within the volume

11

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

408-416

UT code for WoS article

001629381800003

EID of the result in the Scopus database

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