Modulation of tularemia disease progress by the bisquaternary pyridinium oxime HI-6
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F10%3A00002843" target="_blank" >RIV/62157124:16270/10:00002843 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/10:00002307
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Modulation of tularemia disease progress by the bisquaternary pyridinium oxime HI-6
Original language description
Cholinesterase reactivator HI 6 is a drug commonly used to treat individuals exposed to nerve agents Recent experiments proved HI 6 Impact on parasympathetic response and impact on the nervus vagus associated cholinergic anti inflammatory pathway is hypothesized here The modulation effect of HI 6 was studied on BALB/c mice infected with Francisella tularensis the bacteria causing tularemia Cultivation test in vitro confirmed weak bacteriostatic effects of HI 6 Results in experiments revealed intriguingeffect differences resulting from HI 6 administration to mice While the HI 6 dose of 7 mg per animal (pro toto) had no significant effects on infection progress lower dose of 8 jig of HI 6 pro toto reduced mice mortality caused by tularemia infection compared to control group of mice infected only with F tularensis (survival curves were compared by the logrank test chi square = 4 335 df = 1 P = 0 0373) The effect observed in mice exceeded the effect provided in vitro on bacterial culture
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta veterinaria Brno
ISSN
0001-7213
e-ISSN
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Volume of the periodical
79
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
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UT code for WoS article
000285269100014
EID of the result in the Scopus database
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