Effects of sublethal exposure of European brown hares to paraoxon on the course of tularemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F11%3A43870594" target="_blank" >RIV/62157124:16270/11:43870594 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/11:00002586

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Effects of sublethal exposure of European brown hares to paraoxon on the course of tularemia

Original language description

OBJECTIVES: The causative agent of tularemia Francisella tularensis is highly infectious and lagomorphs are important reservoirs and a source of human disease. The aim of the present study was to test the hypothesis that sublethal exposure to pesticidesincreases the susceptibility of hares to F. tularensis and modulates the course of the infection. METHODS: Experimental hares were allocated to a) control, b) paraoxon-treated, c) F. tularensis-treated, and d) paraoxon-and-F.tularensis-treated groups offive specimens on a random basis and subcutaneously inoculated with a wild F. tularensis subsp. holarctica strain (a single dose of 9 x 108 CFU pro toto) and/or injected a sublethal dose of paraoxon (100 mýg/kg). Group differences were evaluated using survival curves, oxidative stress responses as well as caspase-3 and acetylcholinesterase activities in whole blood samples collected on day 2 post exposure. RESULTS: The paraoxon-and-F. tularensis-treated group showed a rapid onset of clin

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

—

Volume of the periodical

32

Issue of the periodical within the volume

—

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

77-83

UT code for WoS article

000300544100010

EID of the result in the Scopus database

—