Sublethal exposure of European brown hares to an anticholinesterase agent paraoxon modulates the course of tularemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F11%3A43870798" target="_blank" >RIV/62157124:16270/11:43870798 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sublethal exposure of European brown hares to an anticholinesterase agent paraoxon modulates the course of tularemia
Original language description
The aim of the present study was to test the hypothesis that sublethal exposure to pesticides increases the susceptibility of hares to F. tularensis and modulates the course of the infection. Experimental hares were allocated to a) control, b) paraoxon-treated, c) F. tularensis-treated, and d) paraoxon-and-F. tularensis-treated groups of five specimens on a random basis and subcutaneously inoculated with a wild F. tularensis subsp. holarctica strain (a single dose of 9 x 108 CFU pro toto) and/or injected a sublethal dose of paraoxon (100 mýg/kg). The paraoxon-and-F. tularensis-treated group showed a rapid onset of clinical signs and all deaths occurred on days 2 and 3 post exposure. F. tularensis-inoculated hares survived from 3 to 10 days, while onlyone hare died on day 12 in the paraoxon-treated group. Survival curves in the three exposé groups were significantly different from the control and median survival in F. tularensis-inoculated and paraoxon-and-F. tularensis-treated hares a
Czech name
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Czech description
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of scientific contributions and abstracts Infectious and Parasitic Diseases of Animals
ISBN
978-80-8077-230-7
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
113-115
Publisher name
Univerzita veterinárného lekárstva Košice
Place of publication
Košice
Event location
Košice
Event date
Sep 7, 2011
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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