Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F11%3A43870591" target="_blank" >RIV/62157124:16270/11:43870591 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/11:00002495 RIV/62157124:16170/11:43870591

Result on the web

<a href="http://dx.doi.org/10.1186/1751-0147-53-2" target="_blank" >http://dx.doi.org/10.1186/1751-0147-53-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1751-0147-53-2" target="_blank" >10.1186/1751-0147-53-2</a>

Result language

angličtina

Original language name

Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model

Original language description

Background: The aim of the present study was to investigate biochemical and oxidative stress responses to experimental F. tularensis infection in European brown hares, an important source of human tularemia infections. Methods: For these purposes we compared the development of an array of biochemical parameters measured in blood plasma using standard procedures of dry chemistry as well as electrochemical devices following a subcutaneous infection with a wild Francisella tularensis subsp. holarctica strain (a single dose of 2.6 x 109 CFU pro toto). Results: Subcutaneous inoculation of a single dose with 2.6 x 109 colony forming units of a wild F. tularensis strain pro toto resulted in the death of two out of five hares. Plasma chemistry profiles were examined on days 2 to 35 post-infection. When compared to controls, the total protein, urea, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase were increased, while albumin, glucose and amylase were decreased. B

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Veterinaria Scandinavica

ISSN

0044-605X

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

2

Country of publishing house

DK - DENMARK

Number of pages

13

Pages from-to

1-13

UT code for WoS article

000286595500001

EID of the result in the Scopus database

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