Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871396" target="_blank" >RIV/62157124:16270/12:43871396 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/12:00194045 RIV/00216305:26620/12:PU100803
Result on the web
<a href="http://web2.mendelu.cz/af_239_nanotech/data/pub/138-12_Sobrova_author.pdf" target="_blank" >http://web2.mendelu.cz/af_239_nanotech/data/pub/138-12_Sobrova_author.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11696-012-0229-0" target="_blank" >10.2478/s11696-012-0229-0</a>

Result language
angličtina
Original language name
Study of deoxynivalenol effect on metallothionein and glutathione levels, antioxidant capacity, and glutathione-S-transferase and liver enzymes activity in rats
Original language description
Deoxynivalenol (DON, vomitoxin) is one of several human mycotoxins acquired through residues in foods of plant origin (cereals) and through foods of animal origin (kidneys, liver, milk, eggs). The aim of this study was to investigate the impact of deoxynivalenol-contaminated mouldy grain on the health status of rats and their ability to resist oxidative stress. The rats were fed a diet supplemented with DON along with organic and inorganic Zn(II), and vitamins for 28 days. The study focuses particularlyon protective mechanisms and levels of reduced glutathione and metallothioneins (MT) against the adverse effects of xenobiotics. The highest concentrations of MT were detected in the tissues of kidneys ((6.70 +- 0.05) mýg g?1) and liver ((6.00 +- 0.05)mýg g?1), both of which are involved in detoxifying cationic xenobiotics. Lower concentrations were also detected in heart, brain, testes, and muscle tissues (approximately 3.0 mýg g?1). Antioxidant capacity, glutathione-S-transferase, an
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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