The gastroprotective effect of oxycellulose pellets on gastric ulcers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872048" target="_blank" >RIV/62157124:16370/13:43872048 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10570-013-9894-6" target="_blank" >http://dx.doi.org/10.1007/s10570-013-9894-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10570-013-9894-6" target="_blank" >10.1007/s10570-013-9894-6</a>
Alternative languages
Result language
angličtina
Original language name
The gastroprotective effect of oxycellulose pellets on gastric ulcers
Original language description
Oxycellulose belongs to the wide range of pharmaceutically and medically used cellulose derivatives unique in its properties of biodegradability, non-toxicity, antioxidative activity, haemostasis supporting, tissue healing improvement, etc. Glycyrrhizin(Gly) represents the most prominent licorice triterpenoid glycoside, which is responsible for its pharmacological activity, and is closely linked to increasing levels of gastroprotective prostaglandins. In order to study the anti-ulcer activity of oxycellulose sodium and Gly, pellets containing only oxycellulose, or in combination with glycyrrhizin, were prepared using an extrusion/spheronization method. The physical properties and in vitro release rate of the prepared pellets were tested. Based on theobtained results, one sample prepared from oxycellulose only, and one containing glycyrrhizin were chosen for in vivo testing. The healing effect of the prepared pellet formulations was evaluated in the acetic acid induced gastric ulcers
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/2A-1TP1%2F073" target="_blank" >2A-1TP1/073: *New pharmaceutical products based on polysaccharides</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CELLULOSE
ISSN
0969-0239
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
1237-1248
UT code for WoS article
000318870500024
EID of the result in the Scopus database
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