The development and in vitro evaluation of herbal pellets coated with Eudragit(R) FS 30 D
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873162" target="_blank" >RIV/62157124:16370/15:43873162 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2014.920355" target="_blank" >http://dx.doi.org/10.3109/10837450.2014.920355</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2014.920355" target="_blank" >10.3109/10837450.2014.920355</a>
Alternative languages
Result language
angličtina
Original language name
The development and in vitro evaluation of herbal pellets coated with Eudragit(R) FS 30 D
Original language description
The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sensitive polymer Eudragit(R) FS. Optimal sample of pellets were prepared using microcrystalline cellulose and lactose as excipients and demonstrated excellent technological quality propertiessuch as Hausner ratio (1.07 +- 0.11) and compressibility index (6.73 +- 0.94%) value, spericity (0.87 +- 0.001) and friability (0.22 +- 0.08 N). Pellets were coated by 10-35% (w/w) of Eudragit(R) FS. Dissolution studies showed that less than 20% of coating could not prevent dissolution of phenols in pH 1.2, 20% Eudragit(R) FS coating is enough to prevent herbal extract against dissolution in the stomach. There were observed no statistical significant differences between 20% and 25% or h
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
ISSN
1083-7450
e-ISSN
—
Volume of the periodical
20
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
769-774
UT code for WoS article
000361337500001
EID of the result in the Scopus database
—