Development of Tablet Medical Form Containing Substance FS-1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873523" target="_blank" >RIV/62157124:16370/15:43873523 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Development of Tablet Medical Form Containing Substance FS-1

Original language description

The original substance of the FS-1 is a nano-ion complex with bactericidal and virucidal activity which was developed in Scientific Center for Anti-infectious Drugs (Almaty, RK) and is intended for the treatment of tuberculosis. The purpose of presentedwork was to develop a rational and optimum technology for preparing of tablets based on the substance of FS-1, and to evaluate the effect of the time of hydrolysis on quality of the developed medical form. For this, 2 batches of FS-1 substance with timeof hydrolysis 17 min and 20 min were synthesized. The aim was to obtain tablets with suitable mechanical properties (friability below 1%) and a suitable disintegration time (up to 15 min), as is required by the Ph.Eur. Optimal formulation and process parameters for the preparation of tablets containing FS-1, under which tablets met the requirements for tablet disintegration time, tablet friability, and tablet mass and content uniformity, were identified within presented work. Longer time

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Research Journal of Pharmaceutical, Biological and Chemical Sciences

ISSN

0975-8585

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

1610-1615

UT code for WoS article

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EID of the result in the Scopus database

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