Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873527" target="_blank" >RIV/62157124:16370/15:43873527 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2015/892671" target="_blank" >http://dx.doi.org/10.1155/2015/892671</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/892671" target="_blank" >10.1155/2015/892671</a>
Alternative languages
Result language
angličtina
Original language name
Formulation of Novel Layered Sodium Carboxymethylcellulose Film Wound Dressings with Ibuprofen for Alleviating Wound Pain
Original language description
Effective assessment and management of wound pain can facilitate both improvements in healing rates and overall quality of life. From a pharmacological perspective, topical application of nonsteroidal anti-inflammatory drugs in the form of film wound dressings may be a good choice. Thus, the aim of this work was to develop novel layered film wound dressings containing ibuprofen based on partially substituted fibrous sodium carboxymethylcellulose (nonwoven textile Hcel NaT). To this end, an innovative solvent casting method using a sequential coating technique has been applied. The concentration of ibuprofen which was incorporated as an acetone solution or as a suspension in a sodium carboxymethylcellulose dispersion was 0.5 mg/cm(2) and 1.0 mg/cm(2) offilm. Results showed that developed films had adequate mechanical and swelling properties and an advantageous acidic surface pH for wound application. An in vitro drug release study implied that layered films retained the drug for a long
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/TA04010065" target="_blank" >TA04010065: Matrix systems for healing of skin defects for human and veterinary use</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
2015
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
"nestránkováno"
UT code for WoS article
000355517900001
EID of the result in the Scopus database
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