Composite scaffolds based on bacterial cellulose for wound dressing application

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F22%3A63558979" target="_blank" >RIV/70883521:28610/22:63558979 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acsabm.2c00226" target="_blank" >https://pubs.acs.org/doi/10.1021/acsabm.2c00226</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsabm.2c00226" target="_blank" >10.1021/acsabm.2c00226</a>

Result language

angličtina

Original language name

Composite scaffolds based on bacterial cellulose for wound dressing application

Original language description

Wound dressing materials fabricated using biocompatible polymers have become quite relevant in medical applications, and one such material is bacterial cellulose (BC) with exceptional properties in terms of biocompatibility, high purity, crystallinity (∼88%), and high water holding capacity. However, the lack of antibacterial activity slightly restricts its application as a wound dressing material. In this work, polycaprolactone (PCL) was first impregnated into the BC matrix to fabricate flexible bacterial cellulose-based PCL membranes (BCP), which was further functionalized with antibiotics gentamicin (GEN) and streptomycin (SM) separately, to form wound dressing composite scaffolds to aid infectious wound healing. Fourier transform infrared spectroscopy (FT-IR) results confirmed the presence of characteristic PCL and cellulose peaks in the composite scaffolds at 1720 cm-1, 3400 cm-1, and 2895 cm-1, respectively, explaining the successful interaction of PCL with the BC matrix, which is further corroborated by scanning electron microscopy (SEM) images. X-ray diffraction (XRD) studies revealed the formation of highly crystalline BCP films (∼86%). In vitro studies of the BC and BCP scaffolds against baby hamster kidney (BHK-21) cells revealed their cytocompatible nature; also the wettability studies indicated the hydrophilicity of the developed scaffolds, qualifying the main criterion in wound dressing applications. Energy dispersive X-ray analysis (EDX) of the drug loaded scaffolds showed the presence of sulfur in the composites. The prepared scaffolds also exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus. The release profiles initially indicated a burst release (6 h) followed by controlled release of GEN (∼42%) and SM (∼58%) from the prepared scaffolds within 48 h. Hence, these results interpret that the prepared drug-functionalized cellulosic scaffolds have great potential as a wound dressing material in biomedical applications.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Applied Bio Materials

ISSN

2576-6422

e-ISSN

—

Volume of the periodical

5

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

3722-3733

UT code for WoS article

000831727300001

EID of the result in the Scopus database

2-s2.0-85136342228