Film wound dressing with local anesthetic based on insoluble carboxymethycellulose matrix

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875609" target="_blank" >RIV/62157124:16370/17:43875609 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jab.2017.08.002" target="_blank" >http://dx.doi.org/10.1016/j.jab.2017.08.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2017.08.002" target="_blank" >10.1016/j.jab.2017.08.002</a>

Result language
angličtina
Original language name
Film wound dressing with local anesthetic based on insoluble carboxymethycellulose matrix
Original language description
The aim of the presented research was to formulate, prepare and evaluate novel film wound dressings containing lidocaine hydrochloride. The conversion of partially substituted fibrous sodium carboxymethylcellulose (CMC) to an acidic form of CMC enabled the formation of an insoluble matrix which consequently provided the prepared films with excellent handling properties in their wet state. The drug concentration which was incorporated into an external layer of the film was 5 mg/cm2. The films demonstrated satisfactory mass and drug content uniformity as well as an acidic surface pH advantageous for wound application. An in vitro drug release test proved that the insoluble CMC matrix served as a reliable carrier without slowing down the release of lidocaine hydrochloride - more than 90% of the drug was released during the first 15 min, indicating a quick rate of anesthetic action. The prepared films could be potential wound dressings for comfortable and efficient topical anesthesia before/after procedures on the wound.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/TA04010065" target="_blank" >TA04010065: Matrix systems for healing of skin defects for human and veterinary use</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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