Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876008" target="_blank" >RIV/62157124:16370/17:43876008 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00098635 RIV/00159816:_____/17:00067699

Result on the web

<a href="http://dx.doi.org/10.1016/j.biopha.2017.03.099" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.03.099</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2017.03.099" target="_blank" >10.1016/j.biopha.2017.03.099</a>

Result language

angličtina

Original language name

Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

Original language description

Background: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO(2)) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. Methods: The study was carried out on three groups of rats: control, MSG- and MSG + nCeO(2). They were injected with saline (control) or MSG. A month after born MSG- rats had been treated with water in a volume of 2.9 ml/kg, MSG + CeO2 groups - with CeO2 intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1 beta, IL-12Bp40, interferon-gamma (INF-gamma)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-beta (TGF-beta)) were measured by ELISA. Results: We have demonstrated the anti- obesity effect of nanocrystalline cerium dioxide and for the first time its anti- inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1 beta, IL-12Bp40) in rat serum and restored the level of anti- inflammatory cytokines (IL-4, IL-10, TGF-beta) to the control values. Conclusion: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti- oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicine &amp; pharmacotherapy

ISSN

0753-3322

e-ISSN

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Volume of the periodical

90

Issue of the periodical within the volume

JUN 2017

Country of publishing house

FR - FRANCE

Number of pages

7

Pages from-to

608-614

UT code for WoS article

000402471000074

EID of the result in the Scopus database

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