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Prenylated phenolic compounds as potential anti-inflammatory substances

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876702" target="_blank" >RIV/62157124:16370/18:43876702 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prenylated phenolic compounds as potential anti-inflammatory substances

  • Original language description

    Natural phenolics can be divided into different categories with the common structural feature of phenolic hydroxyl. The biological activity of such phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of the prenyl connection and modification affects their biological activity. The lecture would shortly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. We would show some of our confirmations of selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Advances in Phytochemical Analysis ? Trends in Natural Products Research

  • ISBN

    978-1-5272-2154-3

  • ISSN

  • e-ISSN

    neuvedeno

  • Number of pages

    1

  • Pages from-to

    107

  • Publisher name

    Phytochemical Society of Europe

  • Place of publication

    Cambridge

  • Event location

    Liverpool

  • Event date

    Jul 2, 2018

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article