Prenylated phenolic compounds as potential anti-inflammatory substances

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876702" target="_blank" >RIV/62157124:16370/18:43876702 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Prenylated phenolic compounds as potential anti-inflammatory substances
Original language description
Natural phenolics can be divided into different categories with the common structural feature of phenolic hydroxyl. The biological activity of such phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of the prenyl connection and modification affects their biological activity. The lecture would shortly summarize the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on the inhibition of cyclooxygenases and lipoxygenases; the effects on the production of nitric oxide, an antiradical and antioxidant activity, and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. We would show some of our confirmations of selected prenylated flavonoids, 2-arylbenzofurans, and stilbenes as potential antiphlogistic substances. The information about the antiphlogistic potential of prenylated phenolics gives the idea that a big pool of natural prenylated phenols represents a source of inspiration for synthesis, and that prenylated phenols are active principles of various medicinal plants used to combat inflammation.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Advances in Phytochemical Analysis ? Trends in Natural Products Research
ISBN
978-1-5272-2154-3
ISSN
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e-ISSN
neuvedeno
Number of pages
1
Pages from-to
107
Publisher name
Phytochemical Society of Europe
Place of publication
Cambridge
Event location
Liverpool
Event date
Jul 2, 2018
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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