Rapid HPLC method for monitoring of lactulose production with a high yield

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43878174" target="_blank" >RIV/62157124:16370/19:43878174 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14160/19:00120952
Result on the web
<a href="https://doi.org/10.1016/j.carres.2019.107773" target="_blank" >https://doi.org/10.1016/j.carres.2019.107773</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carres.2019.107773" target="_blank" >10.1016/j.carres.2019.107773</a>

Result language
angličtina
Original language name
Rapid HPLC method for monitoring of lactulose production with a high yield
Original language description
An HPLC method suitable for rapid monitoring of lactulose production by isomerization from lactose was developed. The separation of lactose and lactulose under hydrophilic interaction liquid chromatography (HILIC) mode was achieved with resolution 1.5 within 5 min. Since isocratic elution was used, there is no extra time necessary for the column equilibration. Application of the method was illustrated on monitoring lactulose isomerization with catalysis of sodium hydroxide in the presence of sodium tetraborate at 70 degrees C (pH = 11). The conversion yield obtained for lactulose was 86%, and corresponding purity 76%. For the first time, a poly-hydroxy stationary phase for separation of lactose and lactulose is reported.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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