Mechanism of deoxynivalenol effects on the reproductive system and fetus malformation: Current status and future challenges

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F17%3A50005608" target="_blank" >RIV/62690094:18450/17:50005608 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.tiv.2017.02.011" target="_blank" >http://dx.doi.org/10.1016/j.tiv.2017.02.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tiv.2017.02.011" target="_blank" >10.1016/j.tiv.2017.02.011</a>

Result language

angličtina

Original language name

Mechanism of deoxynivalenol effects on the reproductive system and fetus malformation: Current status and future challenges

Original language description

Deoxynivalenol (DON) is a toxic fungal secondary metabolite produced by molds of the Fusarium genus, and it is known to cause a spectrum of diseases both in humans and animals, such as emesis, diarrhea, anorexia, immunotoxicity, hematological disorders, impairment of maternal reproduction, and fetal development. The recently revealed teratogenic potential of DON has received much attention. In various animal models, it has been shown that DON led to skeletal deformities of the fetus. However, the underlying mechanisms are not yet fully understood, and toxicological data are also scarce. Several animal research studies highlight the potential link between morphological abnormalities and changes of autophagy in the reproductive system. Because autophagy is involved in fetal development, maintenance of placental function, and bone remodeling, this mechanism has become a high priority for future research. The general aim of the present review is to deliver a comprehensive overview of the current state of knowledge of DON-induced reproductive toxicity in different animal models and to provide some prospective ideas for further research. The focus of the current review is to summarize toxic and negative effects of DON exposure on the reproductive system and the potential underlying molecular mechanisms in various animal models.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology in vitro

ISSN

0887-2333

e-ISSN

—

Volume of the periodical

41

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

150-158

UT code for WoS article

000404701800018

EID of the result in the Scopus database

2-s2.0-85015062859