Trends in the Treatment of Chronic Wounds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18450%2F25%3A50021703" target="_blank" >RIV/62690094:18450/25:50021703 - isvavai.cz</a>

Result on the web

<a href="https://www.eurekaselect.com/article/143044" target="_blank" >https://www.eurekaselect.com/article/143044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0109298673312649240829103906" target="_blank" >10.2174/0109298673312649240829103906</a>

Result language

angličtina

Original language name

Trends in the Treatment of Chronic Wounds

Original language description

Chronic wounds remain one of the significant burdens to health across the world, mainly in view of diabetes and its natural consequences. This category of lesions includes pressure ulcers, vascular diseases, and surgery-related wounds, which affect millions and pose a major challenge to the healthcare industry. The paper reviews the various physiological mechanisms of wound healing, factors that impede it, and some new treatments emerging at this moment. In contrast, current developments include surgical and non-surgical alternatives like topical dressings, medicated formulations, and skin substitutes. Advanced wound care today covers tissue-engineered skin substitutes, 3D-printed wound dressings, topical medicated formulations, and growth factor-based therapies. These are non-invasive, biocompatible methods that are cost-effective, user-friendly, and more conducive to natural healing than traditional therapies. Hydrogel dressings have high water content to create a moist environment that encourages healing. They also reflect excellent physicochemical and biological properties, which enhance autolytic debridement and reduction of pain due to the moisture retention, biocompatibility, and non-toxicity conferred. Tissue-engineered skin substitutes, comprising allogeneic or autologous cells, wound-healing enhancement bioengineered allogeneic cellular therapies are like the natural skin and encourage regeneration. 3D printing allows the production of customized dressings to aid in better treatment. Newer therapies, including bioengineered allogeneic cellular therapies and fish skin grafting, require more clinical trials to confirm safety and efficacy. With such innovations in wound healing technologies and therapies, the future looks quite promising in managing chronic wounds, enhancing healing, reducing healthcare expenditure, and promoting a better quality of life for patients.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current medicinal chemistry

ISSN

0929-8673

e-ISSN

1875-533X

Volume of the periodical

32

Issue of the periodical within the volume

26

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

27

Pages from-to

5370-5396

UT code for WoS article

001314275500001

EID of the result in the Scopus database

2-s2.0-85215073669