Biological safety and tissue distribution of (16-mercaptohexadecyl) trimethylammonium bromide-modified cationic gold nanorods

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50014073" target="_blank" >RIV/62690094:18470/18:50014073 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/18:00494336 RIV/68378041:_____/18:00494336 RIV/68378050:_____/18:00494336 RIV/00179906:_____/18:10368634 RIV/68407700:21340/18:00318348

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0142961217307032?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0142961217307032?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biomaterials.2017.10.044" target="_blank" >10.1016/j.biomaterials.2017.10.044</a>

Result language

angličtina

Original language name

Biological safety and tissue distribution of (16-mercaptohexadecyl) trimethylammonium bromide-modified cationic gold nanorods

Original language description

The exceptionally high cellular uptake of gold nanorods (GNRs) bearing cationic surfactants makes them a promising tool for biomedical applications. Given the known specific toxic and stress effects of some preparations of cationic nanoparticles, the purpose of this study was to evaluate, in an in vitro and in vivo in mouse, the potential harmful effects of GNRs coated with (16-mercaptohexadecyl)trimethylammo-nium bromide ((MTAB)GNRs). Interestingly, even after cellular accumulation of high amounts of (MTAB)GNRs sufficient for induction of photothermal effect, no genotoxicity (even after longer-term accumulation), induction of autophagy, destabilization of lysosomes (dominant organelles of their cellular destination), alterations of actin cytoskeleton, or in cell migration could be detected in vitro. In vivo, after intravenous administration, the majority of GNRs accumulated in mouse spleen followed by lungs and liver. Microscopic examination of the blood and spleen showed that GNRs interacted with white blood cells (mononuclear and polymorphonuclear leukocytes) and thrombocytes, arid were delivered to the spleen red pulp mainly as GNR-thrombocyte complexes. Importantly, no acute toxic effects of (MTAB)GNRs administered as 10 or 50 mu g of gold per mice, as well as no pathological changes after their high accumulation in the spleen were observed, indicating good tolerance of (MTAB)GNRs by living systems.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10610 - Biophysics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomaterials

ISSN

0142-9612

e-ISSN

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Volume of the periodical

154

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

275-290

UT code for WoS article

000419538900022

EID of the result in the Scopus database

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