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Characterization of the Penetration of the Blood-Brain Barrier by High-Performance Liquid Chromatography (HPLC) Using a Stationary Phase with an Immobilized Artificial Membrane

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F18%3A50014450" target="_blank" >RIV/62690094:18470/18:50014450 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/18:43889557 RIV/00216208:11410/18:10376622 RIV/00179906:_____/18:10376622

  • Result on the web

    <a href="http://dx.doi.org/10.1080/00032719.2018.1424175" target="_blank" >http://dx.doi.org/10.1080/00032719.2018.1424175</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/00032719.2018.1424175" target="_blank" >10.1080/00032719.2018.1424175</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Characterization of the Penetration of the Blood-Brain Barrier by High-Performance Liquid Chromatography (HPLC) Using a Stationary Phase with an Immobilized Artificial Membrane

  • Original language description

    The biological activity of drugs on organisms is associated with the pharmacokinetic properties, such as the ability to penetrate through environments of varying polarity such as cellular organelles. In this area, particular attention is turned to the physicochemical properties that determine the potential of drugs to pass across the blood-brain barrier and thus to act on the central nervous system. In this study, special effort has been devoted to the simulation of passive diffusion of seven drugs (propranolol, ibuprofen, atenolol, promazine, chlorpromazine, imipramine, and desipramine) through the blood-brain barrier by high-performance liquid chromatography (HPLC) using a column with an immobilized artificial membrane. Gradient reverse elution was used to develop a linear correlation model for the capacity factors k(IAM) and the in vivo logarithmic values of brain-to-blood drug concentration ratios (log BB) with R of 0.9851. Eleven additional pharmaceuticals were determined by the same method to predict their potential to penetrate the blood-brain barrier. The reported analytical method represents an alternative tool for rapid and noninvasive assessment of the absorption properties of chemicals, especially for the development of novel drugs. The retention of the studied compounds on the immobilized artificial membrane column was also compared with three other C18-based stationary phases. Herein, the results of the HPLC determination of drugs using an immobilized artificial membrane are briefly discussed with respect to a general application of the method for evaluating a broader spectrum of pharmaceutical compounds.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Analytical letters

  • ISSN

    0003-2719

  • e-ISSN

  • Volume of the periodical

    51

  • Issue of the periodical within the volume

    15

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    2401-2414

  • UT code for WoS article

    000436859100007

  • EID of the result in the Scopus database