Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F19%3A50015596" target="_blank" >RIV/62690094:18470/19:50015596 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/19:10394648
Result on the web
<a href="https://www.mdpi.com/1422-0067/20/8/1829/htm" target="_blank" >https://www.mdpi.com/1422-0067/20/8/1829/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms20081829" target="_blank" >10.3390/ijms20081829</a>
Alternative languages
Result language
angličtina
Original language name
Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments
Original language description
The brain has a unique biological complexity and is responsible for important functions in the human body, such as the command of cognitive and motor functions. Disruptive disorders that affect this organ, e.g., neurodegenerative diseases (NDDs), can lead to permanent damage, impairing the patients' quality of life and even causing death. In spite of their clinical diversity, these NDDs share common characteristics, such as the accumulation of specific proteins in the cells, the compromise of the metal ion homeostasis in the brain, among others. Despite considerable advances in understanding the mechanisms of these diseases and advances in the development of treatments, these disorders remain uncured. Considering the diversity of mechanisms that act in NDDs, a wide range of compounds have been developed to act by different means. Thus, promising compounds with contrasting properties, such as chelating agents and metal-based drugs have been proposed to act on different molecular targets as well as to contribute to the same goal, which is the treatment of NDDs. This review seeks to discuss the different roles and recent developments of metal-based drugs, such as metal complexes and metal chelating agents as a proposal for the treatment of NDDs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067
e-ISSN
—
Volume of the periodical
20
Issue of the periodical within the volume
8
Country of publishing house
CH - SWITZERLAND
Number of pages
33
Pages from-to
"Article number: 1829"
UT code for WoS article
000467648700027
EID of the result in the Scopus database
2-s2.0-85065290283