Toxic mechanisms of the trichothecenes T-2 toxin and deoxynivalenol on protein synthesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019138" target="_blank" >RIV/62690094:18470/22:50019138 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/22:10445824
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0278691522002423?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0278691522002423?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fct.2022.113044" target="_blank" >10.1016/j.fct.2022.113044</a>
Alternative languages
Result language
angličtina
Original language name
Toxic mechanisms of the trichothecenes T-2 toxin and deoxynivalenol on protein synthesis
Original language description
The toxic mechanisms of trichothecenes, including T-2 toxin and deoxynivalenol (DON), are closely related with their effects on protein synthesis. Increasing lines of evidence show that T-2 toxin can reduce the levels of tight junction proteins, and nuclear factor erythroid 2–related factor 2 (Nrf2) by disrupting cellular barriers and the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) and Nrf2/heme oxygenase (HO)-1 pathways. Moreover, it can inhibit aggrecan synthesis, thus causing Kashin–Beck disease. Regarding type B trichothecene, DON inhibits activation marker and β-catenin synthesis by acting on immune cells and the wingless/integrated (Wnt) pathway; it also inhibits cell proliferation and immune surveillance. In addition, DON has been shown to destroy tight junctions, glucose transport, and tumor endothelial marker 8, thus disturbing intestinal function and changing cell migration. This review summarizes the inhibitory effects of the trichothecenes T-2 toxin and DON on different protein synthesis, while discussing their underlying mechanisms. Focus is given to the effects of these toxins on tight junctions, aggrecan, activation markers, and hormones including testosterone under the influence of steroidogenic enzymes. This review can extend the current understanding of the effects of trichothecenes on protein synthesis and help to further understand their toxic mechanisms. © 2022 Elsevier Ltd
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21101 - Food and beverages
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food and chemical toxicology
ISSN
0278-6915
e-ISSN
1873-6351
Volume of the periodical
164
Issue of the periodical within the volume
June
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
"Article number 113044"
UT code for WoS article
000829861300006
EID of the result in the Scopus database
2-s2.0-85128712095