Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001301" target="_blank" >RIV/65269705:_____/11:#0001301 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/11:00052704
Result on the web
<a href="http://dx.doi.org/10.1200/JCO.2011.34.7872" target="_blank" >http://dx.doi.org/10.1200/JCO.2011.34.7872</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1200/JCO.2011.34.7872" target="_blank" >10.1200/JCO.2011.34.7872</a>

Result language
angličtina
Original language name
Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in Chronic lymphocytic leukemia
Original language description
Purpose There is a distinct connection between TP53 defects and poor prognosis in chronic lymphocytic leukemia (CLL). It remains unclear whether patients harboring TP53 mutations represent a homogenous prognostic group. Patients and Methods We evaluatedthe survival of patients with CLL and p53 defects identified at our institution by p53 yeast functional assay and complementary interphase fluorescence in situ hybridization analysis detecting del(17p) from 2003 to 2010.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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