Continuous local anaesthetic wound infusion in infants undergoing thoracic or abdominal surgery: A systematic review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00080544" target="_blank" >RIV/65269705:_____/24:00080544 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2949711624000625?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2949711624000625?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yjpso.2024.100177" target="_blank" >10.1016/j.yjpso.2024.100177</a>

Result language

angličtina

Original language name

Continuous local anaesthetic wound infusion in infants undergoing thoracic or abdominal surgery: A systematic review

Original language description

Objective: To determine whether continuous local anaesthetic wound infusion (CLAWI) provides more effective pain relief and decrease the need for systemic opioids compared to other analgesic agents in term or preterm newborn infants undergoing thoracic or abdominal surgery. Methods: Cochrane Central Register of Controlled Trials, Medline, Embase and CINAHL were searched from database inception to August 2022. Publications were screened and their references were hand-searched to identify additional studies. This review included randomized controlled trials (RCTs), quasi-RCTs, and cluster RCTs. Two reviewers independently extracted data and examined the methodological quality of the eligible studies. A meta-analysis was performed for available outcomes. Results: After screening 1202 articles, two RCTs with 98 patients were included. Meta-analysis for combined data was possible for only two outcomes: pain scores post-surgery and length of hospital stay. The random effects model for the pooled standardised mean difference of pain scores between treatment groups post-surgery was -2.54 (95 % CI:7.53, 2.46, p = 0.3196) and for length of stay in the NICU was -0.19 (95 % CI:0.58, 0.21, p = 0.3574), suggesting that CLAWI was not more effective in either providing pain relief or reducing length of stay. However, the small number of studies included, the considerable heterogeneity between the studies, and the small sample sizes of the individual studies limit the generalizability of the findings. Conclusion: This review highlights the need for further, adequately powered well-designed, multicentre trials to examine the effectiveness of CLAWI in reducing postoperative pain in newborns undergoing abdominal and thoracic surgery. Level of evidence: Level I - Evidence from a systematic review of all relevant randomized controlled trials

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30209 - Paediatrics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pediatric Surgery Open

ISSN

2949-7116

e-ISSN

2949-7116

Volume of the periodical

8

Issue of the periodical within the volume

OCT 2024

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

100177

UT code for WoS article

001353527800001

EID of the result in the Scopus database

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