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Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F17%3A00474103" target="_blank" >RIV/67985807:_____/17:00474103 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/17:10362326 RIV/00064165:_____/17:10362326

  • Result on the web

    <a href="http://dx.doi.org/10.1371/journal.pone.0175509" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0175509</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pone.0175509" target="_blank" >10.1371/journal.pone.0175509</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

  • Original language description

    Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10103 - Statistics and probability

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS ONE

  • ISSN

    1932-6203

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000399874800030

  • EID of the result in the Scopus database

    2-s2.0-85017511236