Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F17%3A00474103" target="_blank" >RIV/67985807:_____/17:00474103 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10362326 RIV/00064165:_____/17:10362326
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0175509" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0175509</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0175509" target="_blank" >10.1371/journal.pone.0175509</a>
Alternative languages
Result language
angličtina
Original language name
Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients
Original language description
Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10103 - Statistics and probability
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
12
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
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UT code for WoS article
000399874800030
EID of the result in the Scopus database
2-s2.0-85017511236