Dipeptidyl peptidase IV in two human glioma cell lines.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F00%3A20010202" target="_blank" >RIV/67985823:_____/00:20010202 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/01:23010439

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Dipeptidyl peptidase IV in two human glioma cell lines.

Original language description

Dipeptidyl peptidase IV (DPP-IV) takes part in the metabolism of biologically active peptides participating in the regulation of growth and transformation of glial cells. However, the knowledge on the DPP-IV expression in human glial and glioma cells isstill very limited. In this study, using histochemical and biochemical techniques, the DPP-IV activity was demonstrated in 2 human glioma cell lines of different transformation degree, as represented by U373 astrocytoma (WHO Grade III) and U87 glioblastoma multiforme (WHO Grade IV) lines. Higher total activity of the enzyme, as well as its preferential localisation in the plasma membrane, was observed in U 87 cells. Compared to U 373 population, U 87 cells were morphogically more pleiomorphic, their were less cycling and expressing less GFAP. The data suggests positive correlation between the degree of transformation of cells and activity of DPP IV. The differential expression of this enzyme makes these lines a suitable and standard mod

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/LN00A026" target="_blank" >LN00A026: Center of molecular and cellular immunology</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Histochemistry

ISSN

1121-760X

e-ISSN

—

Volume of the periodical

44

Issue of the periodical within the volume

1

Country of publishing house

IT - ITALY

Number of pages

7

Pages from-to

57-63

UT code for WoS article

—

EID of the result in the Scopus database

—