Genetics of Cd36 and the hypertension metabolic syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A00000066" target="_blank" >RIV/67985823:_____/02:00000066 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/02:00142307
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Genetics of Cd36 and the hypertension metabolic syndrome
Original language description
By combining techniques of gene mapping and gene expression profiling with studies in congenic and transgenic strains, a specific molecular defect in the Cd36 fatty acid transporter has been identified that contributes to the pathogenesis of 2 complex traits in the spontaneously hypertensive rat (SHR). These findings show that a primary defect in fatty acid transport can promote disordered carbohydrate metabolism in the SHR and show the power of advanced genome technologies for identifying QTL at the molecular level
Czech name
Genetika Cd36 a metabolický syndrom
Czech description
Pomocí kombinace vazebných analýz, analýz kongenních kmenů, studia profilů genové exprese a komplementačních studií pomocí transgeneze, jsme odhalili deleční mutaci genu Cd36 jako primární příčinu metabolických poruch u kmene SHR. Cd36 je tak jedním z prvních lokusů kvantitativních znaků, který byl odhalen na molekulární úrovni
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Seminars in Nephrology
ISSN
0270-9295
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
148-153
UT code for WoS article
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EID of the result in the Scopus database
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