Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F03%3A20030080" target="_blank" >RIV/67985823:_____/03:20030080 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Intracellular calcium measurements as a method in studies on activity of purinergic P2X receptor channels.
Original language description
Spatiotemporal characteristics of intracellular Ca2+ signaling and its dependence on current signaling was studied in excitable mouse immortalized gonadotropin-releasing hormone-secreting cells (GT1) and nonexcitable human embryonic kidney cells (HEK-293) cells expressing wild-type and chimeric P2XRs. The temporal characteristics of Ca2+ signals reflected well the receptor-specific EC50 values for ATP and the extracellular Zn2+ and pH sensitivities of P2XRs. These results indicate that intracellular Ca2+ measurements are useful for characterizing the pharmacological and kinetic properties of P2XRs, when the host cells do not express other members of purinergic receptors.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology-Cell Physiology
ISSN
0363-6143
e-ISSN
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Volume of the periodical
285
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
"C467"-"C479"
UT code for WoS article
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EID of the result in the Scopus database
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