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Intracellular spermine decreases open probability of N-methyl-d-aspartate receptor channels

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F04%3A00102565" target="_blank" >RIV/67985823:_____/04:00102565 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378041:_____/04:00109658

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Intracellular spermine decreases open probability of N-methyl-d-aspartate receptor channels

  • Original language description

    Spermine and related polyamines have been shown to be endogenous regulators of several ion channel types including ionotropic glutamate receptros. We propose that intracellular spermine has a direct inhibitory effect on NMDA receptors that is different from calcium-induced NMDA receptor inactivation and spernime-induced voltage-dependent inhibition of AMPA/kainate receptors

  • Czech name

    Intracelulární spermin snižuje pravděpodobnost otevření NMDA receptorů

  • Czech description

    Spermin a další polyaminy jsou endogenními modulátory několika typů ionotropních receptorů včetně glutamátových receptorů. Předpokládáme, že inhibiční účinek intracelulárního sperminu na NMDA receptorech je odlišný od Ca2+-indukované inaktivace NMDA receptorů a sperminem indukované napěťově závislé inhibice AMPA/kainátových receptorů

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neuroscience

  • ISSN

    0306-4522

  • e-ISSN

  • Volume of the periodical

    125

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    879-887

  • UT code for WoS article

  • EID of the result in the Scopus database