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Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F08%3A00320367" target="_blank" >RIV/67985823:_____/08:00320367 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin

  • Original language description

    This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced calcium-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia.In view of the polymodal nature of TRPV1, we illustrate how the channels behave in their desensitized state when activated by noxious heat or depolarizing voltages. We provide a possible explanation for a high incidence of adverse effects of topical capsaicin and point to a need for more accurate clinical criteria for employing it as a reliable remedy

  • Czech name

    Desenzitizace vaniloidního receptoru TRPV1 závislá na vápníku: Možný mechanizmus analgetického účinku lokálně aplikovaného kapsaicinu

  • Czech description

    Naše zjištění vneslo pochybnosti o dosavadních představách založených na posttranslační modifikaci TRPV1 proteinu a závislosti na procesu fosforylace/defosforylace. Autoři dochází k závěru, že problém není dosud dořešen a je součástí komplexu otázek, naněž je nutné odpovědět, abychom porozuměli mechanizmům, které se uplatňují v analgetických účincích kapsaicinu

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    57

  • Issue of the periodical within the volume

    Suppl.3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    10

  • Pages from-to

  • UT code for WoS article

    262473500007

  • EID of the result in the Scopus database