Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F08%3A00320367" target="_blank" >RIV/67985823:_____/08:00320367 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin
Original language description
This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced calcium-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia.In view of the polymodal nature of TRPV1, we illustrate how the channels behave in their desensitized state when activated by noxious heat or depolarizing voltages. We provide a possible explanation for a high incidence of adverse effects of topical capsaicin and point to a need for more accurate clinical criteria for employing it as a reliable remedy
Czech name
Desenzitizace vaniloidního receptoru TRPV1 závislá na vápníku: Možný mechanizmus analgetického účinku lokálně aplikovaného kapsaicinu
Czech description
Naše zjištění vneslo pochybnosti o dosavadních představách založených na posttranslační modifikaci TRPV1 proteinu a závislosti na procesu fosforylace/defosforylace. Autoři dochází k závěru, že problém není dosud dořešen a je součástí komplexu otázek, naněž je nutné odpovědět, abychom porozuměli mechanizmům, které se uplatňují v analgetických účincích kapsaicinu
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
Suppl.3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
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UT code for WoS article
262473500007
EID of the result in the Scopus database
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