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EN
ČeštinaEnglish

Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F10%3A00342116" target="_blank" >RIV/67985823:_____/10:00342116 - isvavai.cz</a>

  • Result on the web

    —

  • DOI - Digital Object Identifier

    —

Alternative languages

  • Result language

    angličtina

  • Original language name

    Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

  • Original language description

    The article focuses on the problematic of temperature dependence of deactivation of native N-Methyl-D-Aspartate (NMDA) receptors in neuronal cultures and the temperature dependence of excitatory postsynaptic currents mediated by synaptic NMDA receptors in rat cortical slices. Our electrophysiology experiments found that both native as well as synaptic receptors exhibit significantly weaker temperature dependence compared to recombinant GluN1/GluN2B NMDA receptors. Synaptic NMDA receptors have characteristics of receptors with low desensitization (20%). Double exponential time course of NMDA receptor deactivation originates mainly from dissociation of agonist and desensitization

  • Czech name

    —

  • Czech description

    —

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

    —

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neuroscience

  • ISSN

    0306-4522

  • e-ISSN

    —

  • Volume of the periodical

    165

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    13

  • Pages from-to

    —

  • UT code for WoS article

    274002600011

  • EID of the result in the Scopus database

    —

Similar results(10)

Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependentEndogenous antagonists of N‐methyl‐d‐aspartate receptor in schizophreniaAnti-N-Methyl-D-Aspartate Receptor Encephalitis