Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F10%3A00351994" target="_blank" >RIV/67985823:_____/10:00351994 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/10:00351994

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia

Original language description

Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. We hypothesize that adaptive responses to chronic hypoxia are the result of altered transcriptional regulations in the right and left ventricles. Here we report results from the gene expression profiling of adaptive responses in a chronically hypoxic heart. Of 11analyzed candidate genes, the expression of seven and four genes, respectively, was significantly altered in the right ventricle of hypoxic male and female mice. In the transcriptional profile of the left ventricle, we identified a single expression change in hypoxic males (Vegfa gene). To directly test the role of HIF1, we analyzed the expression profile in Hif1a partially deficient mice exposed to moderate hypoxia

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA301%2F09%2F0117" target="_blank" >GA301/09/0117: Molecular Mechanisms in Diabetic Embryopathy</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Physiology

ISSN

8750-7587

e-ISSN

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Volume of the periodical

109

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000285344900033

EID of the result in the Scopus database

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