Conserved Residues within the Putative S4?S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F10%3A00354172" target="_blank" >RIV/67985823:_____/10:00354172 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Conserved Residues within the Putative S4?S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels
Original language description
Based on the structural similarity to voltage-gated potassium channels, the voltage-sensing domain in the TRP channels is hypothesized to be comprised of positively charged amino acids distributed within the transmembrane segments S1-S4. Our data providethe first functional evidence that, despite the highly conserved nature of S4 and the S4-S5 linker, the mechanisms of temperature and chemical sensitivity in TRPV1 appear to utilize different residues from those in TRPV2 and TRPV3, which indicates thatthese mechanisms are not fully conserved throughout thermosensitive TRPV channels. This conclusion is further supported by our finding that one specific mode of chemical activation of TRPV1 is separable from other activation mechanisms and depends on onebasic residue in the S4/S4-S5 domain
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
285
Issue of the periodical within the volume
53
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
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UT code for WoS article
285622600031
EID of the result in the Scopus database
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