Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00365459" target="_blank" >RIV/67985823:_____/11:00365459 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/11:00365459
Result on the web
<a href="http://dx.doi.org/10.1097/NEN.0b013e31822c256d" target="_blank" >http://dx.doi.org/10.1097/NEN.0b013e31822c256d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/NEN.0b013e31822c256d" target="_blank" >10.1097/NEN.0b013e31822c256d</a>
Alternative languages
Result language
angličtina
Original language name
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
Original language description
This research article is first report of the role of spastin in cell motility. The enzyme spastin is from microtubule-severing ATPases and regulates lenght of microtubules. Among strategies used for treating malignant tumors belongs disrupting the integrity of microtubules. The role of microtubules on invasivity has the higher propensity especially in glioblastoma cells from brain. To find the answer to question, if spastin and microtubules regulation somehow influence each other, spastin expression evaluation and testing of intracellular distribution was performed in human glioblastomas and astrocytes. It was found that spastin expression is increased in tumor cells. Surprisingly, functional experiments comparing the effects of spastin depletion on the motility and proliferation in glioblastomas have shown decreased motility and higher proliferation rate. The article proposes that spastin in glioblastomas might be linked to tumor cell invasion.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuropathology and Experimental Neurology
ISSN
0022-3069
e-ISSN
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Volume of the periodical
70
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
811-826
UT code for WoS article
000294247700008
EID of the result in the Scopus database
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