Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00369138" target="_blank" >RIV/67985823:_____/11:00369138 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1471-4159.2011.07463.x" target="_blank" >http://dx.doi.org/10.1111/j.1471-4159.2011.07463.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1471-4159.2011.07463.x" target="_blank" >10.1111/j.1471-4159.2011.07463.x</a>

Result language
angličtina
Original language name
Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor
Original language description
Purinergic P2X receptors are ubiquitous, ligand-gated cationic channels activated by extracellular ATP. The P2X3 receptors, which are involved in nociception, are known for their very fast and complete desensitization, which persists for many minutes. Structural modeling followed by experimental validation of predictions suggested conserved tyrosine 37side chain is needed for the stabilization of the closed receptor state while kinetic modeling specifies that lack of Y37 results in destabilization of closed desensitized states
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—

Project
<a href="/en/project/IAA500110910" target="_blank" >IAA500110910: Structure and function of receptors activated by extracellular ATP</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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