Modulation of spinal cord synaptic activity by tumor necrosis factor ? in a model of peripheral neuropathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00372591" target="_blank" >RIV/67985823:_____/11:00372591 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1742-2094-8-177" target="_blank" >http://dx.doi.org/10.1186/1742-2094-8-177</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1742-2094-8-177" target="_blank" >10.1186/1742-2094-8-177</a>

Result language
angličtina
Original language name
Modulation of spinal cord synaptic activity by tumor necrosis factor ? in a model of peripheral neuropathy
Original language description
The cytokine tumor necrosis factor a (TNFa) is an established pain modulator in both the peripheral and central nervous systems. Modulation of nociceptive synaptic transmission in the spinal cord dorsal horn (DH) is thought to be involved in the development and maintenance of several pathological pain states. Increased levels of TNFa and its receptors (TNFR) in dorsal root ganglion (DRG) cells and in the spinal cord DH have been shown to play an essential role in neuropathic pain processing. In the present experiments the effect of TNFa incubation on modulation of primary afferent synaptic activity was investigated in a model of peripheral neuropathy
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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